http://www.colonchat.net/forum/viewtopic.php?f=1&t=2564&sid=1ef9f3edb99154feef1da3776553143e
Maybe some discussion about these very hot topics changing the GOLD STANDARD OF CARE. WHO CARES WELL WE SEE?
For friends with colorectal cancer. As I am banned here and there on the net could any cancer survivors network old friends share this study as it means we pay a very high price for oxaliplatin for not much gain. Yes this is in vitro, not in vivo but it's worth asking your conventional oncologist.
FUNDAMENTALLY ITS GOOD WE THE PATIENTS DEMAND AND TEST OUR DOES EVERY TIME WE MEET THEM. THE YES SIR NO SIR 3 BAGS FULL SIR APPROACH IS LET HAD. BUT I GET PERILOUSLY CLOSE TO SHEEP ANALOGY AND TEST GOT ME BANNED.
IRONICALLY BEING BANNED GAVE ME MORE FOCUS ON MY RESERVE AND LESS HELP FOR OTHERS ON CSC SURVIVORS NETWORK. THOSE I LOVED MOSTLY GONE NOW!
TO THINK CRAZY EXERCISE MADE IS GOING A WORLD CLASS DENDRITIC CELL CONFERENCE WITH THE MOST INNOVATIVE RESERVE IN THE COLORECTA UNIVERSE. In case you did not know.
Will do one off medium dose 5-FU to kills CSC Monday released doing biopsy and microwave ablation last Thursday. Survival needs this level of focus, research and care. Ask your doctor. Sorry but he want have a clue.
Another earthquake colorectal paper, the SOC failing like mcdonalds
https://www.researchgate.net/publication/282010420_Gene_Expression_Changes_in_Colorectal_Cancer_during_Metronomic_Chemotherapy_and_HighConcentration_Drug_Administration
Is this a game changer? Probably yes
My respect for rgcc has increased, the $5000 spent 4 years on there test worth it when I see colorectal research I can use
Efficacy of 5-FU or Oxaliplatin Monotherapy over Combination Therapy in Colorectal Cancer
https://www.researchgate.net/publication/275251678_Efficacy_of_5-FU_or_Oxaliplatin_Monotherapy_over_Combination_Therapy_in_Colorectal_Cancer
4. Discussion There has been great progress in the development of CRC treatment; however, a high percentage of patients relapse after treatment, indicating that improved treatments are still required. Drug resistance is the biggest issue in increasing the efficacy of chemotherapy. Based on the CSC hypothesis, which suggests that rare populations of tumor-initiating cells, among others, may lead to resistance to therapy, the present study investigated the effect of 5-FU and oxaliplatin chemotherapeutic drugs administered in combination or as monotherapy in such cells.
5-FU is a pyrimidine analog that inhibits thymidylate synthase. 5-FU causes cell cycle arrest in the post-G1/ pre-S phase and induces apoptosis by inhibiting DNA synthesis and by interacting directly or indirectly with several enzymes [26]. 5-FU enters the cell by a facilitated nucleobase transporter and is converted to its main active metabolites (FdUMP, FdUTP, and FUTP) by a complex metabolic pathway. It is thought to be cytotoxic to tumor cells via three potential mechanisms: inhibition of thymidylate synthase by FdUMP; incorporation of FdUTP into DNA; and incorporation of FUTP into RNA [27]. In the present study, genes encoding enzymes involved in these reactions included TYMS, SHMT1, DNMT1, DPYD and DHFR. TYMS catalyzes the methylation of deoxyuridylate to deoxythymidine, while DPYD is responsible for the degradation of uracil and thymine. SHMT1 plays an important role in nucleic acid biosynthesis, and DHFR reduces dihydrofolic acid to tetrahydrofolic acid. Tetrahydrofolate and its derivatives are essential for purine and thymidylate synthesis [28]-[31]. Previous studies in CRC demonstrated that the response to 5-FU varies in CRC cell lines [32]. In this study, it is remarkable that DPYD is not expressed in CSCs but only in HCT-116 cells. However, the gene expression disappaers after 192 or 240 h of incubation. This is also supported by a previous study, which demonstrated that colorectal tumors responding to 5-FU have low gene expression levels of dihydropyrimidine dehydrogenase [33]. The absence of DPYD in CRC stem cells could explain the effect of 5-FU; however it does not explain why monotherapy seems to be better than combination therapy. The effect of oxaliplatin was tested by studying the expression of ERCC1, a gene that encodes a DNA excision repair protein. According to a previous study, high expression of ERCC1 is correlated with resistance to platinum chemotherapy, as platinum compounds form crosslinks in DNA that inhibit DNA synthesis [34]. Previous studies have suggested FOLFOX in combination with other regimens such as curcumin to treat CRC cells [35] [36]. The present work is an in vitro pharmacodynamic study that attempted to compare the effect of 5-FU and oxa- liplatin or their combination in HCT116 CRC cells and a colon CSC line. Data were generated by treating the
two different populations with the two drugs separately or in combination over a time window of 10 days (240 h). Despite the fact that these two cell population had totally different hallmarks, the results from the viability assays showed that the cell responses were almost comparable. According to the gene expression data, single use of 5-FU seemed to be more effective than in combination with oxaliplatin for both cell lines. However, there were differences in the response time: in CSCs, better results appeared after 192 h and 240 h treatment, while in HCT-116, 5-FU was more effective at 144 h. These observations may explain the resistance of CSCs over short incubation times, in contrary to HCT-116, where there was greater inhibition at shorter times. Specifically, in CSCs there was an increase in gene expression at shorter incubation times, which then decreased. Concerning each specific gene, no linearity was evident among them even though they are involved in similar pathways. However, in viability assays the percentage of dead cells increased in correlation with the incubation time. In conclusion, the present study demonstrated that single use of 5-FU might have a better effect on CRC and colon CSCs compared with oxaliplatin or their combination. The viability of cells was decreased in both cell lines, while the gene expression pattern differed in CSCs. Moreover, gene expression profile should be studied for at least 10 days to ensure reliable results. In summary, this is the first report that monotherapy may be more effective; however, further larger studies are required. Acknowledgements
Another day yippee!
http://nocamels.com/2015/01/new-vaccine-for-cancer/
Watch the video, so simple and clear like my blog. Ha ha
https://youtube/JGsSEqsGLWM
Just nice refresher for b17, John beards troposphere blast theory of cancer.
I had a call from a really partner of someone with cervical cancer, it's easier to chat for 20minutes than do long emails smart phone.
My point is ill share my experience with anyone who is brave enough to leave the standard of care. Too look beyond red tape, to dream of impossible cures.
I still more than likely have some cancer somewhere, but I feel so very fine.
The super coffee and milk thistle enemas working.
I got a little grinder. I grind fresh daily milk thistle, b17 kernels and flax seeds. I enjoy this grind with my progurt super probiotic yogurt and frozen berries.
Rectal basal temp 37.03 some immune activation.
Before doctors I really on God to heal. He gave us brains. Minds and souls to learn. Grow and appreciate this world. His greatest gift.
It's the X mass season. With every Xmas commercial I close my eyes and say thank you jesus. My very simplistic view is that it's all about love, everything else white noise.
I enjoy listening to John Lennox but the arguments esoteric, we need less thinking, more action and real love.
I am thinking of really doing the 40 turkey leg thanks giving project.
Yes I must be nuts.
Please pray for all in need, the pain. The hopes and suffering and dreams of my friends and readers real.
Jesus please grant us all our miracles!
Time for another enema.
So my liver has been burned 10 to 20%. I'll heal it within a week and get inflammation under control
Henry Liang the world's best tcm cancer specialist and my friend. Knows more than Dr Chang who is famous. Henry knows me, and what it takes for late stage 4 comebacks.
See the emails. But read the fzhy paper. As always bend red tape not brake it. If you must cut it. Then tape it back together so our brutally ignorant and lethal authorities never know it's been cut.
I met Anna a reader and an amazing wife.
Love heals. But to prevail over cancer must come from within the patient not the patients partner
INTO FZHY TCM TO HEAL LIVER POST MICROWAVE ABLATION.
ONLY HENRY RESPONDED
Hello Peter,
Nice to hear from you!
FZHY is a commonly-used method of Chinese medicine for chronic liver diseases. It may be beneficial for protecting liver function and preventing liver fibrosis. FZHY is not a herb or herbal formulation, but a therapeutic method/principle. Many herbal formulas have this function, but which one is suit able for you, that needs to be checked by Chinese medicine practitioners.
I am happy to see you when you come back.
Take care
Henry
From: Peter Trayhurn [mailto:petetrayhurnhtc@gmail.com]
Sent: Saturday, 21 November 2015 1:22 AM
To: Henry Liang
Subject: Fwd: Fzhy Tom formula . East meets west in germany
▼ Hide quoted text
Dearest henry
I am very well. I hope you are.
See email below any comment fzhy?
I see you after 19dec when I come home
I am alive!
Cheers,
Pete
---------- Forwarded message ----------
From: "Peter Trayhurn"<petetrayhurnhtc@gmail.com>
Date: 20/11/2015 3:00 PM
Subject: Fzhy Tom formula . East meets west in germany
To: GERMANY TCM DOCTORS
Cc:
Dear doctors
I Need this ASAP to boost liver healing reduce fibrosis
http://www.hindawi.com/journals/ecam/2015/125659/
Any other ideas suggestions. I cannot source Frankfort today!
Cheers,
Pete
SHARING MY TRUTH ON THE GCMAF FORUM
Wow, so much caring advice here, our cancers unique and change moment to moment they are troublemakers like noakes that cause pain. Progression a sign to do something better different ASAP. I'm trying new gcmaf rerum and methadone for my metastatic cancer which comes and goes. Almost all who try gcmaf for late stage die, please God if I am wrong tell me. I need hope, it's never as simple as the snake oil salesmen say. But I have faith in gcmaf in combo, I like lesser comment about fatty acids. We really don't know much about details. It's Xmas and I believe in miracles, may we all get ours
THE THE ABOUT CANCER THIS WEEKS NEWS LETTER EXCELLENT, I JUST BOUGHT APRICOT KERNELS AND I HAVE BEEN HAVING BROCCOLI SPROUTS FOR 4 YEARS NOW. I USE EN DURELL FROM MY FRIEND CHRISTINE. OPEN THE LINKS DID NOT WORK. I LIKE THAT TO IS OPEN ABOUT COMMISSIONS. JUST LIKE MY DOCTORS GIVE ME DISCOUNTS. BUT LIKE TO I RECOMMEND MY DOCTORS BECAUSE I HAVE FAITH IN THEM. ARE THEY PERFECT? NO, BUT I AM ALIVE! THAT ENOUGH.
Your TTAC Newsletter: Advanced Cancer Preventions and Treatments
Hi peter,
I hope you're having an amazing weekend so far! :-)
Real quick, before we get into this week's articles and videos below, I just wanted to give you a heads-up about some free documentaries that are currently playing on FMTV Live that I think you'll love.
FMTV LIVE is a powerful live streaming event (similar to our docu-series) that’s happening from November 20th-30th. It will be showcasing some of the world’s leading health and wellness documentaries, as well as live Q&A interviews with the experts themselves!
Plus, the best thing about this event is that it’s completely online, open to absolutely everyone, and it’s 100% FREE!
Go here to learn more and watch these fascinating documentaries for free today.
And as always, be sure to read this week's exclusive articles below and share them with your friends and family.
Ty Bollinger
The Landmark Johns Hopkins Sulforaphane Cancer Study Your Doctor Isn't Telling You About
The landmark john hopkins
Want to prevent cancer? Learn about the Johns Hopkins University study into the incredible cancer-fighting properties of sulforaphane.
Read More
Did Sandra Lee's Doctors "Lie" to Her About DCIS?
Did sandra lee s doctors
Was celebrity chef Sandra Lee's double mastectomy for DCIS really necessary? Learn what every woman needs to know about ductal carcinoma in situ (DCIS).
Read More
Video - The Best Sources of Laetrile (aka Vitamin B17 or Amygdalin) for Cancer Patients
The best sources of laetrile
Laetrile, amygdalin, and vitamin B17 are different names for the same cancer-fighting substance. Learn where you can find it.
Read More
How The Budwig Diet Protocol for Cancer Works
How the budwig
The Budwig Diet has been used to successfully treat cancer and a variety of other diseases. Discover why it works and how to make the Budwig Diet mixture.
Read More
Video - Why Your MD Won't Recommend a Natural Treatment
Why your md wont recommend
Looking for a natural treatment for disease or prevention advice instead of a pill? Here's why most doctors can't (or won't) help.
Read More
“The best and most efficient pharmacy is within your own system.”
~ Robert C. Peale
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