Merry pavolova

Merry xmas everyone.

This is the best xmas yet. I enjoyed a wonderful xmas lunch of turkey, snapper,prawns and pavolova. The saphire gin and tonic on ice im sure killed some tumour cells. Back on ketogenic diet tomorrow.

I got the ttf tumour treating fields devices by post for xmas. I have started wearing jacket and sleeping ttf blanket. See blog a few days ago about ttf science.

I have high hopes for this technology.

The family had a great xmas day and my 20kg german box of presents arrived that i unpack. Its got my special rerum nebuliser and really very precious medicines.

Ive spent monday tuesday Wednesday getting infusion equipment. Iv c supplies ie 60 bottles. My present from my son was helping cleanup setup the office on xmas morning.

My bloods on 23dec came back and cea jumped from 227 to 333 so i hope this is still a spike from final german treatments. The liver enzymes really bad and my creatinin kinase 2000 highest doctors have seen indicating severe muscle catabolism from nivolumab autoimmune.  I called onc then surgeon then alternative about my extreme and dangerous result. No answers or replies xmas eve which i expected. My gp local doctor who gave result said highest he ever seen and can cause kidney failure but he said i was ok.

So i wait and pray. We enjoyed midnight mass.

The next few tests crucial to see whats happening.

Its great to be alive with these challenges and opportunities.

I am joyfully focused as ever and i treasure my wifes abd kids very kind care as im recovering slowly physically from nivolumab side effects and possibly the heavy german treatments.

I Restarted dca celebrex met res art sel lefsupp yesterday. Mild diarrhea. 2xbravo yogurt.

I got this great link from anna

http://www.m.webmd.com/vitamins/ai/ingredientmono-49/lactoferrin/source-2

http://dx.doi.org/10.1155/2014/184278

I was searching and found this thread.

http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=46263&p=421984#p421984

http://www.hindawi.com/journals/isrn/2014/184278/

To think ive been blessed to make this yogurt for almost 4 years now. The saurkraut with bifido strains and yogurt with lactoferrin and so much more. 

I wish id had friends who could see how blessed ive been to find and trust many of these therapies. Instead ive taken refuge here in my blog and left the cancer masses to there tragic avoidable deaths as im powerless really to help beyond offering my own story.my little adventure. 

I relish this life.

I dream of remission and i start the most advanced colorectal protocols ever attempted in my little office in sydney.

Another xmas with my loving wife and kids.

I am blessed. We all are.

The bugs and viruses have always played a big part. 

I just did coffee ebema 1000000 and enjoyed 20 minutes in far infared sauna and some thc cbd oil.

This is a time for love and healing and miracles for all in need.

God bless us all!

Ps my favourite present

to gaze into my wifws blue eyes and see her smile despite the ordeal my survival causes my family. In my greatest hours of need and incapacity ive been loved beyond hope and measure. Thats much sweeter than sex.

She brings me popcorn in the bath. Organic of course.mild ketosis ok today.

Remember ENOUGH what we all do is ENOUGH in fact its perfect

BUT THE SECOND TREASURE WAS A CHRISTMAS WISH TO MY MIRACLE. WHAT COULD I SAY TO THE DOCTOR I OWE MOST TO.

Ho ho ho from sydney my dearest prof. Life is the best gift thanks. Best wishes to you and yours

SO MANY IGNORANT AND CRITICAL COMMENTS ON THE NET. I DONT HAVE THE TIME OR ENERGY TO DEFEND MY HERO. I THE THREAD ABOVE THEY CRITICIZE VOGL FOR POOR REN AGAIN WHEN I CELEBRATE A DOCTOR WHO TAKE A RISK TO GIVE ME THE ONLY CHANCE IVE GOT. THEY ARE RARE LIKE PRECIOUS JEWELS.

I CANNOT GET MY ONC SURGEON OR ALT DOCTOR HERE IN SYDNEY TO INSERT MY CHEMO PORT NEEDLE AS I DO UNAPPROVED THERAPY THAT GIVES ME THE BEST SHOT AT LIFE.

SO I TEACH MY 14 YEAR OLD DAUGHTER AND WIFE HOW TO BE MY NURSE.  THE CARE OF THE PALLIATIVE HERE IN SYDNEY IS AS COMPASSIONATE AS THE GAS CHAMBERS GUARDS SMILES!

So all experience unique as is suffering. I reflect on chemo suffering and extreme muscle loss. I now have this immunotherapy induced extreme pain and muscle loss. What makes the unrelieved pain bearable is at least i have high hopes of immunotherapy success which is so different to conventional cancer  therapies. Its pain i gladly endure as it will pass. Its diminishing day by day. Thats why no pain relief. I must know how the autoimmune dysfunction reverses.

My wisdom and opinion has been earnt with much suffering for that im very grateful. 

Gods plan is magnificent! For us all! His will be done!

FOR THE CLEVER

Discussion

Percentages of CD4⁺CD25⁺FOXP3⁺ and CD8⁺CD28^– Tregs were higher in patients with NSCLC than in control subjects with nonmalignant lung disease in the present study. In addition, CD4⁺CD25⁺FOXP3⁺ and CD8⁺CD28^– Treg populations increased with tumour progression, which is consistent with findings from other cancer types.^{10,11,19⇓–21} In accordance with findings in early stage prostate cancer,⁸ the present study indicated a higher percentage of CD4⁺CD25⁺FOXP3⁺ and CD8⁺CD28^– Tregs in early stage NSCLC patients compared with control subjects.

It is thought that Tregs may play a crucial role in inhibiting anticancer defence, and their depletion or suppression may therefore represent an important strategy to prevent tumour immune escape.^12,22 Chemotherapy was traditionally thought to be deleterious to antitumour immunity, but some chemotherapy agents may have the potential to augment anticancer immunity by inhibiting immune tolerance and suppression. Paclitaxel has been found to inhibit the number and function of CD4⁺CD25⁺FOXP3⁺ Tregs directly.²³ In addition, cyclophosphamide was reported to inhibit the activity of CD4⁺CD25⁺ Tregs,¹⁴ and the generation and function of CD8⁺CD28^– Tregs.²⁴ In contrast, arsenic trioxide, dacarbazine, 5-fluorouracil and methotrexate increase the frequency of Tregs in peripheral blood mononuclear cells activated with T-cell mitogen.²⁵ The above data suggest that chemotherapeutic agents may have varying effects on Treg populations and activity.

Percentages of CD4⁺CD25⁺FOXP3⁺ and CD8+CD28^– Tregs were significantly reduced following chemotherapy in the present study. To our knowledge, this is the first study to focus on changes in Treg subpopulations in the peripheral blood of patients with NSCLC undergoing gemcitabine plus cisplatin chemotherapy. Our findings suggest that, in addition to inducing tumour cell death via cytotoxic effects, gemcitabine plus cisplatin exert anticancer activity by decreasing the numbers of circulating Tregs in these patients. The fact that CD4⁺CD25⁺FOXP3⁺and CD8⁺CD28^– Treg postchemotherapy percentages remained higher than those of control subjects suggests that the remaining cancer may continue to feed the mechanism underlying the raised Treg levels.

The present study has several limitations. The study population was small, necessitating the merging of subgroups for statistical analyses. As a result our findings should be interpreted cautiously, since a larger sample size is needed. In addition, it was outside the scope of our study to determine whether the CD4⁺CD25⁺FOXP3⁺ and CD8⁺CD28^– cells we identified displayed suppressive activity. Consequently we cannot categorically state that these cells are regulatory/suppressive T cells. Chemotherapy may not only decrease Treg number but also inhibit functionality,^23,26 and further investigations into functional changes will allow insight into the immunoregulatory effect of gemcitabine plus cisplatin chemotherapy. Our study investigated combination gemcitabine and cisplatin chemotherapy, and it is not possible to extrapolate our findings to determine the impact of each agent individually. This could be overcome via dose–response analysis of single agents in animal models. Finally, NK cells provide a first line of defence against infections and malignant cells, but our study found no significant differences in NK-cell percentages between patients and controls, as well as before and after chemotherapy. NK cells have been reported to be dysfunctional in a number of cancers,^27⇓–29 and to be affected in various ways by exposure to chemotherapeutic agents.^{30⇓⇓⇓–34} Further studies are required to investigate the function of NK cells during chemotherapy, and to explain more fully the relationship between chemotherapy and antitumour immunity.

In conclusion, CD4⁺CD25⁺FOXP3⁺ and CD8⁺CD28^– Treg percentages were higher in patients with NSCLC than control subjects with nonmalignant lung disease, and increased in line with tumour progression. Percentages of CD4⁺CD25⁺FOXP3⁺ and CD8⁺CD28^– Tregs were significantly reduced following gemcitabine plus cisplatin chemotherapy.