I DROVE DAUGHTER TO WORK
PICKED UP VIT C, ALA, GIVING SETS, BICARB IVs AND REFERAL TO PSMA SPECIALIST FROM DOCTORS
YUMCHA WITH SON
MOVIES WITH FRIEND AND SON
ATTEMPED TO FIX PHONE AND LAPTOPS FAILED
PICKED UP DAUGHTER FROM WORK
DINNER KIDS RSL CLUB, WIFE MISSONG IN ACTION NO IDEA SHE GONE WALKABOUT
CRASHED 2 HOURS SLEEP EARLY EVENING EXHAUSTED, STILL MOST WALKING AND DRVING TODAY, I SENSED I WAS PUSHING MYSELF HARD.
STARTED INFUSIONS 11PM, FAST HIGH DOSE VIT c, DOING TAUROLIDINE ALL NIGHT!
SWEET DREAMS, I DID THE RESEARCH BELOW WHILE VIT C RAN!
Hum Pathol. 2009 Dec;40(12):1754-61. doi: 10.1016/j.humpath.2009.06.003. Epub 2009 Aug 27.
Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers.
Haffner MC1,
Kronberger IE,
Ross JS,
Sheehan CE,
Zitt M,
Mühlmann G,
Ofner D,
Zelger B,
Ensinger C,
Yang XJ,
Geley S,
Margreiter R,
Bander NH.
Abstract
Prostate-specific membrane antigen (PSMA), a type II transmembrane metallo-peptidase highly overexpressed in prostate cancer cells, has been studied as a targeting molecule in prostate cancer. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. Because of its unique expression pattern limited to tumor-associated endothelial cells, PSMA may also be an interesting molecule for vascular targeting. In this study, PSMA expression was determined by immunohistochemistry in 119 cases of primary gastric adenocarcinoma, 130 cases of primary colorectal adenocarcinoma, and 24 metastasis of colorectal adenocarcinoma. Expression data were correlated with clinicopathologic information. PSMA expression was detected in tumor-associated neovasculature of 79 (66%) of 119 gastric and 110 (85%) of 130 colorectal carcinomas. Furthermore, the neovasculatures of 16 (84%) of 19 liver and 4 (80%) of 5 nodal metastases from colorectal carcinomas were prostate-specific membrane antigen positive. There was a trend for high-grade tumors to higher PSMA expression (Spearman r = 0.18, P = .046) in colorectal cancers. No association between PSMA expression and overall- or disease-free survival was observed in gastric or colorectal cancers. This study provides the first in-depth look at PSMA expression in gastric and colorectal cancer. Because of its highly tumor-restricted expression and its accessibility to targeted therapy, PSMA represents a promising therapeutic and diagnostic target in colorectal and gastric cancer. SO AGAIN A PROMISING CLINICAL TARGET THATS HIGHLY RESTRICTED AND IS RELEVANT TO MY TUMOUR BURDEN BASED ON METAVECTUM, OF COURSE ILL DO MY IMMUNOTHERAPIES IN TANDOM BUT OUR IMMUNE SYSTEMS NEED ALL THE HELP THEY CAN GET. THE STRATEGY AND RATIONAL IS SELF EVIDENT IF YOUVE BEEN FOLLOWING THE BLOG THE LAST FEW THOUSAND PAGES AND COME ON THE STAGE 4 SURVIVAL JOURNEY WITH ME, I HAVE A REFERAL TO THE PSMA SPECIALIST IN AUSTRALIA WHO A GOOD FRIEND HAS SEEN AND SO I HAVE HOPE.
TONIGHT 2 X QERCETIN, DMSO ALA BICARB VITC TAUROLIDIN ALL NIGHT.
TODAY THE MOST WALKING PRETTY CHALLENGING BUT STILL THE MOST WALKING.