Some friends have enrolled! Its nice to have company.
This is the school i belong to with a metastatic illness with a terminal prognosis.
The only thing that is unique about me is that i believe i can study and experiment my ass off and dream of saving my own life.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656629/ relevant to most solid tumours,
I am using interesting aspect of immunotherapy school to delve deeper into areas of curiousity that may pay big bonuses.
Pubmed is free, i suspect my salvation lies in science and good old fashioned experiments, thats why i am the rat. If the vaccine today gets me, well its been soooo much fun, i just wanted a bit more.
on the subject of miracles. once upon a time a famous immunotherapist was being interviewed. Please dont use the word miracle i said. Survival is only 99.99% guaranteed for cancer. We still have work to do. Maybe one day not one will be lost and then humanity can get onto the real challenges likes obestity and greed and and toxity.
I can dream cann't I.
But of course i am dreaming. And from this patients point of view, is not an extra split second of existence of this magnificent life a miracle. Well for me it is.
So life is just an infinite series of miracles. Thats how I feel, maybe you do to?
I think its ok for my doctors to use the m word liberally, as far as I am concerned there is no such thing as false hope from what I have seen.
This is the school i belong to with a metastatic illness with a terminal prognosis.
The only thing that is unique about me is that i believe i can study and experiment my ass off and dream of saving my own life.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656629/ relevant to most solid tumours,
I am using interesting aspect of immunotherapy school to delve deeper into areas of curiousity that may pay big bonuses.
Pubmed is free, i suspect my salvation lies in science and good old fashioned experiments, thats why i am the rat. If the vaccine today gets me, well its been soooo much fun, i just wanted a bit more.
on the subject of miracles. once upon a time a famous immunotherapist was being interviewed. Please dont use the word miracle i said. Survival is only 99.99% guaranteed for cancer. We still have work to do. Maybe one day not one will be lost and then humanity can get onto the real challenges likes obestity and greed and and toxity.
I can dream cann't I.
But of course i am dreaming. And from this patients point of view, is not an extra split second of existence of this magnificent life a miracle. Well for me it is.
So life is just an infinite series of miracles. Thats how I feel, maybe you do to?
I think its ok for my doctors to use the m word liberally, as far as I am concerned there is no such thing as false hope from what I have seen.
Myofibroblasts in tumor stroma
Clinicians and pathologists have known that certain types of tumors are distinctly hard on palpation (“desmoplastic”) and may in some instances contract neighboring tissues to the point of retracting skin visibly.34 These “scirrhous” tumors result from an abundant fibrous stroma, which is now known to be attributable to the myofibroblasts' deposition and contraction of a collagen-rich ECM by cancer-associated fibroblasts (CAFs, also termed tumor-associated fibroblasts [TAFs]).44–46 Importantly, CAFs are heterogeneous and include FSP-1–positive cells that are SM α-actin–negative or positive.46 These myofibroblast functions, while aiding diagnosis by palpation, also underlie an important feature because this tissue stiffness has recently been shown to support tumor progression that in turn promotes further myofibroblast differentiation.47,48 CAFs play a central role in this “feed-forward” loop, which is a recurring theme in fibrotic settings and provide important paracrine signals to tumor cells.36,49 The concept that the microenvironment of tumors and wounds share important features was originally proposed by Dvorak and has served as an important impetus for recent work in this area.50,51
In summary, myofibroblasts or related “activated” fibroblasts are present in certain normal tissues and transiently in acute wounds where they deposit ECM and exert functionally appropriate mechanical tension on the tissue microenvironment thereby promoting homeostatic mechanisms. However, the extracellular and intracellular network of signals supporting this homeostasis can be disrupted in a spectrum of pathologies. As a result, feed-forward loops are established that can lead to inappropriate mechanical and paracrine signals that perpetuate pathologies such as contractures, tumor growth, and fibrosis. We will now take a closer look at the mechanisms that support the genesis and longevity of myofibroblasts.
SO MAYBE THE ONCOTHERMIA ENHANCES OXYGENATION AND REDUCES HYPOXIA , IT ENHANCES TACE, BY ALLOWING IMMUNE SYSTEM ACCESS TO CHEMOTACTICS, EVEN THEN THE IMMUNE CELLS HAVE ACCESS TO OXYGEN FOR O3, H2O2 AND HOCL-. MAYBE QIGONG AND BREATHING AND MOVING REALLY DOES HELP.
THE MECHANICAL ASPECT OF THIS PAPER IS WHAT ATTRACTED ME.
EVERY ASPECT OF OUR BIOLOGY IS A MIRACLE, AS WELL AS LIFE ITSELF.
http://www.ncbi.nlm.nih.gov/pubmed/23877328
No serious treatment-related AEs were observed. Median survival time (MST) from diagnosis and from the first vaccination was 18.5 and 7.2 months, respectively. By multivariate Cox proportional hazard analysis, the significant independent factors were found to be (1) combined chemotherapy, (2) albumin level ≥4.0 g/dL before vaccination, (3) C-reactive protein level <0.5 mg/dL before vaccination, and (4) fever after vaccination. The MST from the first vaccination with or without chemotherapy was 8.2 and 5.3 months, respectively (P = 0.016), and MST for the patients with prognostic nutritional index ≥40 and <40 was 8.1 and 5.0 months, respectively (P = 0.023).
CRP ALBUMIN NUTION RE DC SURVIVAL