The asco highlights.
Note I was on tamoxifen per the angio genisis foundation, sulforaphane thanks to christine from enduracell and I have been exercising. all these off label, supplement and lifestyle based benefits. Ok not all the trials indicated here just for colorectal, but I know enough about the benefits to extrapolate the benefit.
I have to go for a high intensivity workout, ! are you ? if you got cancer and are well enough you are mad if you don't as long as its within you grasp.
To have ones judgement confirmed, my insight going back three years, gives me great confidence that indeed I am not mad, just a genius. I told you so, is a very painful sentence given how many friends have died without the benefit of these simple therapies.
This is the proof in a sense that convicts the conservative patients, its ok if they don't want to try anything that has merit. what is criminal is the way they dissuade new diagnosed that all these alternatives are rubbish.
All I have ever said that if you got a terminal prognosis and you want to fight, well have a go. dont play it safe, you already got a death sentence more than likely. what the conservatives do is effectively say well, now we will tie your hands behind your back, and lets see how long you survive. The issue I found personally offensive is we will tie our love and support of you to you accepting our beleifs and ideas regarding conventional therapies.
Am I Doing Enough?
well what you have done is what you have done is enough.
I dont think regrets achieve anything in this game of survival.
that said I would order an rgcc profile and as a minimum pickup some targetted supplements that your circulating stems and tumour cells may be susceptible to.
this test will show if you have a low, med or high risk of recurrence.
if you risk is high or medium you can take other steps at reducing it.
of course exercise, sulforaphane and the life extension recommendations are a good place to start.
focusing on a strong immune system, well thats also a good activity , but challenging to achieve.
hugs,
Pete
PS I always ask that question ? am i doing enough! my answer which is YES, gives me a degree of peace regardless how I end up with this disease. I my books doing more now, buys you are more peaceful passing if it comes to that, hopefully though all the effort buys you a long healthy life. see the post about asco and exercise.
Radio frequency ablation on lung metastasis
ask prof morris at saint hospital sydney
Newhe is my hipex surgeon, he also makes rfa devices in his spare time.
in the liver they do up to 7 centimeter.
an option besides rfa is tace to the lung, its only done in germnay by professor vogel to my knowledge.
I know a few who had lung tace , I myself, limited side effects, and good control. that said my lung met still had an suv 0.5 down from 1.1 a year ago.
I don't know who is the best regarding rfa, but prof morris was on tv last night, its nice to know your doctors are famous and well regarded.
rfa is interesting, I need to do more research, but I just figured this doc is good, any day now I might get the call, I wonder if he will rfa the lung met and my liver met.
since you asked, for dispersed lung disease I beleive dendritic cell vaccine with new castle vaccine virus offers the best results per doctor nesslehut, of course he delivers the service and its not proven by a clinical trial.
hugs,
Pete
ps great question, I saw the rfa device , looks amazing.
ASCO highlights, how long will it take for these organisations to implement these results for patients ?
will the onc who said, exercise, sulforaphane and tamoxifen apologise to all the dead ? I doubt , its too late.
I have always said, maybe our onc could be slightly more humble, they could be slightly more perrimive then dismissive.. Again that request fell of deaf ears, but I asked and proved the point that medical arrogance kills. mayvbe oncs should goto to the conferences I attend, then they will know about the starsin the sky and many pathways that tumours have to evade our drugs. maybe something beyond a drug is whats needed. so for the time being, just see the onc as a paid sales rep of the drug company, get your drug from your onc, but get your medical care elsewhere. I am livid about the lives lost of my friends, of the risks I face due to their negligence. The legal class action is coming, it wont be a day to soon. Its fine, if your not negligent, then the doctors have nothing to worry about. if I was in their shoes I would be moving their assets into the partners names, actually its possibly already been done. all the treatment standards are done at limiting medical negligence suits, not improving patient outcomes. thats why they treat of stupid statistical models and fail to practice personailsed medicine.
big pharma chasing big profits thanks kenji, its not profit, but lives, i want too believe this, yes i am delusional. cancer patients vulnerable in the money
nano particles and hyperthermia
Fox Chase Researchers Uncover Novel Mechanism of Promising Drug Treatment for Colon Cancer
Based on these findings, Borghaei and his team set out to explore how Ari-4175 triggers immune system responses to inhibit the growth of tumors with KRAS mutations more effectively than cetuximab alone. In the new study, they applied Ari-4175 to a mouse model of colon cancer. They found that the drug expanded a subpopulation of myeloid cells, which make up one major lineage of blood cells that can activate the immune system. The expansion of the myeloid cell population led to an increase in the production of inflammatory cytokines and the subsequent activation of natural killer cells—white blood cells that recognize and kill tumor cells. In addition, they found that a subset of granulocytes are increased in this model and might be responsible for killing of colon cancer cells bearing KRAS mutations.
“We’re showing evidence that the immune system is activated, and that’s how we think Ari-4175 is leading to a better tumor response. “Patients should be interested because this could potentially open up a new area of research on orally bioavailable drugs that can be used to manipulate the immune system as a single agent or in combination with other active drugs. From a clinical perspective, this is very interesting, and it’s worthy of further research.”
| Long-Term Tamoxifen Benefit for Breast Cancer Confirmed Anna Azvolinsky, PhD Women diagnosed with estrogen-receptor (ER)-positive breast cancer who took tamoxifen for 10 years as adjuvant therapy had lower risk of late recurrence and lower risk of death compared to those who took the drug for 5 years. These results corroborate the findings of the international ATLAS trial. | |
| Sulforaphane in Prostate Cancer Found Worthy of Further Investigation Michael Kaufman In a small trial, treatment with 200 µmol per day of sulforaphane for 20 weeks was "feasible, safe," and inhibited histone deacetylase (HDAC) function in a single-arm study of 20 patients who had non-castrate biochemical (PSA)-recurrence of prostate cancer despite surgery or radiation, results that could form the "basis for dose-escalation studies of sulforaphane." | |
| Staying Fit Could Ward Off Lung and Colorectal Cancer for Middle-Age Men Anna Azvolinsky, PhD A large study shows that middle-age men engaged in lots of cardiovascular exercise have a reduced risk of developing and dying from lung and colorectal cancer. | |
| DNR Completion at End of Life Influenced by Perception of Caregiver Support Leah Lawrence Results of a new study indicated that patients with terminal cancer are more likely to have completed a do-not-resuscitate order when they prefer, and believe that their caregiver prefers, comfort at the end of life. | |
| Pomalidomide New Standard of Care in Heavily Pretreated Relapsed Multiple Myeloma Leah Lawrence Pomalidomide in combination with low-dose dexamethasone had a highly significant benefit on progression-free survival and overall survival compared with single-agent high-dose dexamethasone in patients with relapsed or refractory multiple myeloma, according to updated results of the MM-03 trial presented at the ASCO 2013 Annual Meeting. | |
| For Painful Bone Mets, Single Fraction Irradiation Noninferior to Multiple-Fraction Therapy Leah Lawrence The use of a single 8 Gy fraction of re-irradiation for the treatment of painful bone metastases was noninferior to multiple fractions, according to the results of the NCIC CTG SC.20 trial presented at the ASCO 2013 Annual Meeting in Chicago. |