Started Using Ginger. Survival my strong point not spelling and grammar.
I will save the cancer world from my little office in Dr Siebenheuner's clinic and my life of course.
Ok, I sincerely apologize for my lousy English in all the previous blog pages and web posts. My spelling and grammar were not my strong point. Maybe ginger can help me. The blog just got clearer and more valuable. See how adaptable we are, surely we can beat this illness. If I of all people can now write reasonable sentences, then maybe a cure for cancer is possible. You see we can always have hope, learn and improve.
I suggest you will have a chance of passing your exams in the Immunotherapy University. Just marvel at the wonderful mess humanity has herself in, and our awesome potential. This paper gives me a lot of hope! Our resiliency internally is reflected at a cellular level is also evident in the external actions of man.
To graduate from my Immunotherapy, University, all you have to do is live! I'll email your degree as a survivor as soon as you get into NED no evidence of metastatic disease! Let's just accept conventional scans as proof of NED, and a whole range of super biomarkers for super NED, known as SNED. Which, as a minimum has tktl1 and apo10 and ldh and many other of my doctors esoteric markers which I will publish as we go forward with treatment and testing and results.
What did I get out of the paper above?
In many solid cancers, at any one time-point, the proportion of actively dividing cancer cells is estimated to be of the order of 20%–40% of the total cell population within the tumor mass(es).5 This is because the cells in a malignant mass divide asynchronously and haphazardly. This fact means that with any one dosing administration the maximum proportion of cancer cells that can be influenced by the cytotoxic agent(s) is around 30%, leaving some 70% unable to be effected by the agent(s). Repeated dosing is assumed to randomly influence the remaining cancer cells in the tumor mass when those cells commence divisions at later time-points.
So in the last two weeks the reduction of combined Tace/ipt/oncothermia/immune stimulation/vaccination resulted in 66% shrinkage by volume of only remaining liver met. During the same period a 90% reduction in my CEA tumour marker fell from 204 to 20. Now I assume the CEA proteins measured in the blood are proportional to tumor volume on a patient by patient basis. I conclude that my visible liver metastasis is more cyst now thantumour and I attribute this to my therapy synergy a significant part I suspect is immune response. My hypothesis attempts to explain the relative differences my decreased marker with respect to the liver metastasis volume. If you reference the pet ct , well you will note the 2.5 cm metastasis seems to be missing in action. Prof Vogl did not see it.
So the remaining CEA level I suspect represents 7 is attributable to the lung mets and the remainder likely the liver. This would likely have changed as of yesterday combined Tace and ipt and oncothermia. I will measure CEA a week on Wednesday.
There is emerging clinical evidence that the immune system undergoes dynamic regular homeostatic oscillations in patients with advanced cancer, and therefore there is likely a regular alternating expansion of the effector arm, followed by the regulatory arm, of the immune system that occurs in most, if not all, cancer patients.6–9 This means that the timing of administration of the chemotherapeutic agent within this dynamic framework is also likely to be critical in determining not only the side-effects and morbidity, but in determining the direction that the immune system is driven – either activation/responsiveness or inhibition/tolerance, and thereby determining the clinical outcome.